Disease  Effects 
Alzheimer’s disease  Antinflammatory, antioxidant, antiapoptotic in in vitro and in vivo models of Aβ-evoked neuroinflammatory and neurodegenerative responses. 
Parkinson’s disease  Attenuation of the dopaminergic impairment in vivo; neuroprotection; improvement of psychiatric rating and reduction of agitation, nightmare and aggressive behaviour in patients. 
Multiple sclerosis  Improved signs of EAE in mice, antinflammatory and immunomodulatory properties. 
Huntington’s disease  Neuroprotective and antioxidant in mice transgenic models; no significant clinically important differences in patients. 
Hypoxia-ischemia injury  Short term neuroprotective effects; inhibition of excitotoxicity, oxidative stress and inflammation in vitro and in rodent models. 
Pain  Analgesic effect in patients with neuropathic pain resistant to other treatments. 
Psychosis  Attenuation of the behavioural and glial changes in animal models of schizophrenia; anti-psychotic properties on ketamine-induced symptoms 
Anxiety  Reduction of muscular tension, restlessness, fatigue, problems in concentration, improvement of social interactions in rodent models of anxiety and stress; reduced social anxiety in patients. 
Depression  Anti-depressant effect in genetic rodent model of depression. 
Cancer  Antiproliferative and anti-invasive actions in a large range of cancer types; induction of autophagy-mediated cancer cell death; chemopreventive effects. 
Nausea  Suppression of nausea and conditioned gaping in rats 
Inflammatory diseases  Antinflammatory properties in several in vitro and in vivo models; inhibition of inflammatory cytokines and pathways. 
Rheumatoid arthritis  Inhibition of TNF-α in an animal model 
Infection  Activity against methicillin-resistant Staphylococcus aureus 
Inflammatory bowel and Crohn’s diseases  Inhibition of macrophage recruitment and TNF-α secretion in vivo and ex vivo; reduction in disease activity index in Crohn’s patients. 
Cardiovascular diseases  Reduced infarct size through anti-oxidant and anti-inflammatory properties in vitro and in vivo. 
Diabetic complications  Attenuation of fibrosis and myocardial dysfunction 

 

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